Pseudocatalase cream plus calcium has been
developed originally by Schallreuter et al and was used as a substitution for
low catalase levels in the treatment of vitiligo (KU Schallreuter et al.
Treatment of vitiligo with a topical application of pseudocatalase and
calcium in combination with short term UVB exposure, Dermatology (1995)
190:223-229). The word pseudocatalase has been introduced by these authors to
differentiate between the natural enzyme catalase and a chemical complex which
does the same job, i.e. degrading hydrogen peroxide (H2O2).
In this context, it is noteworthy that catalase protein cannot penetrate the
top layer of the skin. Therefore, any products containing natural catalase in a
cream are basically ineffective, and any product advertised as catalase in the
treatment of vitiligo should be used with caution.
- Repigmentation with pseudocatalase cream
PC-KUS can be achieved in all skin colours and is independent of the percentage
of depigmented skin and the duration of the disease. First signs of
repigmentation can be observed after 2-4 months.
- This treatment modality can also successfully
repigment lips, ears and genitals. However, the response on fingers and feet is
(Schallreuter et al, Dermatology (1995) 190:223-229)
- The removal of high levels of epidermal H2O2
with narrowband UVB-activated pseudocatalase PC-KUS coincides with stabilization
of the depigmentation process followed by repigmentation.
(Schallreuter et al, Dermatology (1995) 190:223-229, J Invest
Dermatol (2001) 116:167-174, Int J Dermatol (2002) 41:482-487)
- The treatment has no side effects providing
the liver function of the affected individual is normal.
(Schallreuter et al, Dermatology (1995) 190: 223-229)
- A significant faster initiation of
repigmentation can be induced with the combination of climatotherapy at the Dead
Sea together with pseudocatalase PC-KUS over a period of 21 days. First
repigmentation occurs between days 14-20. This fast repigmentation lasts for an
additional 3-4 months combined with daily treatment using low-dose narrowband
UVB-activated pseudocatalase PC-KUS. This repigmentation is stable!
(Schallreuter et al, Int J Dermatol (2002) 41:482-487)
- The shelf life of pseudocatalase PC-KUS is 2
years, if stored at room temperature (20°C).
Pseudocatalase PC-KUS has been successfully used in
over 1000 patients. The drawback is, that this treatment modality is a very
disciplined approach and needs an individual treatment plan.
The results are excellent regardless of skin color, age of patient, extent and
duration of the disease.
Dead Sea Pictures
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